Spatial and temporal dimensions of mu-opioid receptor signalling: implications for the development of tolerance

吗啡作为止痛药的使用仍然受到诸如耐受性等不良副作用的限制。尽管经过了几十年的研究，但人们对耐药性形成背后的机制知之甚少。μ阿片受体是一种在细胞表面表达的蛋白，是吗啡的靶细胞。该项目将以前所未有的分辨率研究阿片类药物引发的信号事件，并旨在阐明为什么吗啡比其他阿片类药物更能引起耐受性。

The use of morphine as an analgesic is still limited by undesirable side effects such as tolerance. Despite decades of research, the mechanisms behind the development of tolerance are poorly understood. The μ opioid receptor is a protein expressed at the surface of the cells that is the target of morphine. This project will investigate the signalling events triggered by opioids with unprecedented resolution and will aim to elucidate why morphine elicits more tolerance than other opioid drugs.