Testing and treatment for prostate cancer in Australia: Epidemiology and modelling

我们的目标是使用观察数据和数学模型来研究澳大利亚前列腺癌的检测和治疗。我们将纳入前列腺特异性抗原（PSA）检测和临床实践的变化，以调查：a）过度诊断，即通过PSA检测诊断的癌症病例，否则不会被诊断; B）PSA检测对前列腺癌死亡率的影响;以及c）不同PSA检测方案下的死亡率和医疗保健使用。

We aim to use observational data and mathematical modelling to investigate testing and treatment for prostate cancer in Australia. We will incorporate changes in prostate-specific antigen (PSA) testing and in clinical practice to investigate: a) over-diagnosis, being cancer cases diagnosed through PSA testing that would not have been otherwise diagnosed; b) the effect of PSA testing on prostate cancer mortality; and c) mortality and health care use under different PSA test scenarios.