The therapeutic value of targeting Wnt signalling for the treatment of Osteoarthritis

骨关节炎(OA)影响着162万澳大利亚人，并给医疗保健带来了巨大的负担。它的特点是关节软骨受损，随着骨刺的形成而增加骨形成。我们的研究将确定Wnt信号通路在介导骨性关节炎关节退变中的重要性，并确定调控该途径在骨性关节炎中激活的机制。这将为开发新的治疗策略提供信息，这些策略可以阻止骨关节炎的关节损害。

Osteoarthritis (OA) affects 1.62 million Australians and imposes a significant burden on healthcare. It is characterised by damage to joint cartilage, and increased bone formation with formation of bone spurs. Our studies will determine the importance of the Wnt signalling pathway in mediating OA joint degeneration and identify mechanisms that regulate the activation of this pathway in OA. This will inform the development of novel therapeutic strategies which could halt joint damage in OA.