TNF traffic and secretion in astrocytes and microglial cells: unveilling new targets for ischemic stroke

神经退行性疾病与灾难性神经毒性具有相似的途径，其通过从神经胶质细胞释放细胞因子如肿瘤坏死因子-a（TNF）而发生。TNF控制炎症，但其在大脑中的过度分泌是非常有害的。TNF分泌的机制尚不清楚，但旨在减少其分泌的策略具有治疗潜力。该基金建议研究TNF的分泌，以找到减少分泌的新方法，并在中风模型中提供保护。

Neurodegenerative disorders share a similar pathway to disastrous neurotoxicity, which occurs through the release of cytokines such as tumour necrosis factor-a (TNF) from glial cells. TNF controls inflammation but its excessive secretion in the brain is highly detrimental. The mechanism of TNF secretion is unknown but strategies aimed at reducing it have therapeutic potential. This grant proposes to study TNF discharge to find new ways to reduce secretion and confer protection in a stroke model.