Optimization methods for total marrow irradiation using intensity modulated radiation therapy

据估计，2008年加拿大将诊断出超过4500例新的白血病病例和7900例新的淋巴瘤病例(加拿大癌症协会，2008年)。在美国，这些数字上升到44,000个新的白血病病例和74,000个新的淋巴瘤病例(SEER癌症统计评论，1975-2005)。这些疾病以及许多其他疾病的一种常见治疗方法是骨髓移植。作为患者骨髓移植准备的一部分，患者现有的骨髓必须被根除。这通常是通过化疗和全骨髓照射(TMI)的组合来实现的。

It is estimated that over 4,500 new cases of leukemia and 7,900 new cases of lymphoma will be diagnosed in Canada in 2008 (Canadian Cancer Society, 2008). In the US, those numbers rise to 44,000 new cases of leukemia and 74,000 new cases of lymphoma (SEER Cancer Statistics Review, 1975-2005). A common treatment for these diseases, as well as many other diseases, is bone marrow transplantation. As part of a patient's preparation for a bone marrow transplant, the patient's existing bone marrow must be eradicated. This is typically achieved through a combination of chemotherapy and total marrow irradiation (TMI).