Statistical methods in clinical trials and epidemiology studies

在接下来的五年中，我将进行以下主题的研究：我感兴趣的是开发新的统计方法来分析流行病学和临床试验中的聚集性复发事件。在许多临床研究中，复发事件数据是指某一事件在一段时间内可能反复发生。例如，在心血管试验中，中风可能随着时间的推移反复发生；癌症患者可能经历肿瘤的复发转移；器官移植患者可能会经历多次排斥反应。我将研究聚类循环事件的累积平均函数的非参数估计。我将扩展聚类循环事件数据的方法，并利用和估计聚类主题之间的相关结构。

During the next five years, I will conduct research on the following topics: I am interested in developing new statistical methods for the analysis of clustered recurrent events in epidemiology and clinical trials. In many clinical studies, recurrent event data arise when certain event may occur repeatedly over a period of time. For example, in cardiovascular trails, strokes may occur repeatedly over time; cancer patients may experience recurrent metastases tumors; patients with organ transplant may experience multiple rejection episodes. I will study the nonparametric estimate of the cumulative mean function of cluster recurrent events. I will extend methods for clustered recurrent events data and exploit and estimate the correlation structure among clustered subjects.