Understanding the Assembly of Poxvirus Immature Particles

天花是一种古老而可怕的疾病，它极大地影响了人类历史，仅在20世纪就造成了超过3亿人的死亡。美国出现猴痘病毒人感染病例，以及天花可能被用作生物恐怖主义武器，这些都要求澳大利亚紧急改善对天花病毒的准备。我们研究这些病毒的组装，以促进我们对痘病毒生物学的基本理解，并提供合理设计的药物来对抗它们。

Smallpox is an ancient and dreadful disease that enormously influenced human history causing over 300 millions of deaths in the 20th century only. Human cases of monkeypox virus in the US and the potential use of smallpox as a bioterrorism weapon have called for an urgent improvement in Australia's preparedness against poxviruses. We investigate the assembly of these viruses to advance our fundamental understanding of poxvirus biology and provide rationally designed drugs to fight them off.