Understanding Natural Killer Cell Development and Target Recognition

癌症和癌症免疫疗法的免疫检测和根除或控制在一定程度上是基于肿瘤特异性白细胞可以保护身体免受肿瘤发展、生长和转移的影响。虽然强有力的证据支持这一点，但这些白细胞最初识别癌症组织的方式在很大程度上是未知的。我们将研究一种新的白细胞受体家族，无论是自然识别还是治疗后识别，这一家族可能都很重要。

Immune detection and eradication or control of cancer and cancer immunotherapies are based in part on the idea that tumour-specific white blood cells can protect the body from tumour development, growth and metastases. While strong evidence supports this, the means by which these white cells first recognize the cancerous tissue is largely unknown. We will study a new family of white blood cell receptors that may be important in this recognition, either naturally or following therapy.