Ussing chamber station for the measurement of current produced by transpithelial ion movement

这项设备请求是为了一个Ussing室内空间站。萨斯喀彻温大学的一位新教员将使用这种仪器来测量细胞间盐分移动产生的电流。申请者将在他的研究计划中广泛使用这些设备，通过测量氯的一种成分在呼吸道(或气管)内的细胞中的运动。从长远来看，他的研究计划将开发更深入的蛋白质知识，这种蛋白质被称为通道，允许氯化物从细胞外移动到呼吸道表面。氯化物用它吸水，从而适当地补充呼吸道的水分，保护它免受感染。这项研究将有助于更好地了解影响加拿大人的呼吸系统疾病，如囊性纤维化、哮喘和慢性阻塞性肺疾病(COPD)，并将导致创新疗法的开发。这种新设备对于申请者研究计划的有效执行至关重要。唯一可用的设备是25年前的，速度慢，不可靠，有时还不准确。新设备的容量更大，结果将更快；由于其年龄和质量，它将更加可靠；由于其新的电子设备，它将提供更准确的结果，并同时运行更多样本。

This equipment request is for an Ussing chamber station. This apparatus will be used by a new faculty member at the University of Saskatchewan for the measurement of current produced by salt movement across cells. The applicant will make extensive use of the equipment in his research program by measuring the movement of chloride, a component of salt, in cells lining the airway (or windpipe). In the long term, his research program will develop a more in-depth knowledge of proteins called channels that allow the movement of chloride out of cells and onto the airway surface. The chloride pulls water with it, thus properly hydrating the airway and protecting it against infection. This research will lead to a better understanding of respiratory diseases that impact Canadians, such as cystic fibrosis, asthma, and chronic obstructive pulmonary disease (COPD), and will lead to the development of innovative treatments. This new equipment is crucial for effective execution of the research program of the applicant. The only equipment available is 25 years old, slow, unreliable, and at times inaccurate. The new equipment will produce results faster because of its larger capacity, be reliable because of its age and quality, give more accurate results because of its new electronics, and run more samples simultaneously.