A recording system for ERPs in nonhuman primates

事件相关电位（ERP）是一种与刺激、记忆、注意力或运动行为相关的大脑反应。脑电图（EEG）是一种通过颅骨和头皮测量脑电活动的方法，可以相对容易地测量erp。erp是通过对数百次试验中正在进行的脑电图活动进行平均来获得的，这样随机的大脑活动就被平均掉了，而相关的大脑活动仍然存在。erp已经使用了几十年，在《自然》、《科学》、《神经元》和其他主要期刊上出现了大量的文章。令人惊讶的是，各种ERP组成部分背后的神经过程仍然知之甚少。一个主要的障碍是我们无法记录大脑中单个神经细胞的活动以及头皮上的erp。为了解决这个问题，我们开发了一个非人类灵长类动物模型来充分理解单个神经元活动和erp之间的关系。在这里，我们需要一个电生理记录系统，它将允许我们记录多个大脑区域的单个神经细胞的活动，以及高密度的erp。这个记录系统可能进行的实验将促进我们对各种ERP组件的神经起源的理解。

An event-related potential (ERP) is a brain response associated with a stimulus, memory, attention, or a motor act. ERPs can be measured relatively easily by using electroencephalography (EEG), a method that measures electrical activity of the brain through the skull and scalp. ERPs are obtained by averaging the ongoing EEG activity of hundreds of trials so that random brain activity is averaged out and the relevant brain activity remains. ERPs have been used for several decades and numerous articles have appeared in Nature, Science, Neuron and other leading journals. Surprisingly, the neural processes that underlie the various ERP components are still poorly understood. A major obstacle has been our inability to record the activity of single nerve cells in the brain together with the ERPs on the scalp. To address this problem, we have developed a nonhuman primate model to fully understand the relationship between single neuron activity and ERPs. Here, we are requesting an electrophysiological recording system that will allow us to record the activity of single nerve cells in multiple brain areas together with high-density ERPs. The experiments that are possible with this recording system will advance our understanding of the neural origin of various ERP components.