Statistical methods in clinical trials and epidemiology studies

在接下来的五年里，我将进行以下主题的研究：我有兴趣开发新的统计方法，用于分析流行病学和临床试验中的聚集性复发事件。在许多临床研究中，当某些事件可能在一段时间内重复发生时，就会出现复发事件数据。例如，在心血管试验中，中风可能会随着时间的推移反复发生；癌症患者可能会经历复发的转移肿瘤；器官移植患者可能会经历多次排斥反应。我将研究集群经常性事件的累积平均函数的非参数估计。我将扩展用于聚类重复事件数据的方法，并开发和估计聚类对象之间的关联结构。

During the next five years, I will conduct research on the following topics: I am interested in developing new statistical methods for the analysis of clustered recurrent events in epidemiology and clinical trials. In many clinical studies, recurrent event data arise when certain event may occur repeatedly over a period of time. For example, in cardiovascular trails, strokes may occur repeatedly over time; cancer patients may experience recurrent metastases tumors; patients with organ transplant may experience multiple rejection episodes. I will study the nonparametric estimate of the cumulative mean function of cluster recurrent events. I will extend methods for clustered recurrent events data and exploit and estimate the correlation structure among clustered subjects.