Molecular Basis for the Mitochondrial Stress Response

线粒体应激反应的分子基础。线粒体的生物发生依赖于线粒体和核基因组的协调表达。关于这两种细胞基因组的表达是如何协调的以及协调的程度，人们知之甚少。我们已经发现了一种新的生物学过程，即线粒体应激反应，其中线粒体内应激的建立导致细胞核中编码蛋白质的一组基因的上调，这些蛋白质将线粒体从应激引起的损伤中拯救出来。这个项目是为了确定压力是如何在神经元中被感知并传达到细胞核，从而导致基因表达的改变。该项目还旨在确定线粒体伴侣在细胞器中蛋白质折叠中的生理作用。

Molecular Basis for the Mitochondrial Stress Response. The biogenesis of mitochondria depends on the co-ordinated expression of mitochondrial and nuclear genomes. Little is known about the extent and how the expression of both cellular genomes is co-ordinated. We have discovered a novel biological process, the mitochondrial stress response, whereby the establishment of stress within the mitochondria results in the upregulation of a suite of genes in the nucleus encoding proteins which rescue mitochondria from damage caused by stress. This project is to determine how stress is sensed in the mitochondrion and communicated to the nucleus resulting in alterations in gene expression. The project also aims to define the physiological role of mitochondrial chaperones in protein folding in the organelle.