A ROBOTIC NMR SPECTROMETER FOR ACCELERATED DRUG DISCOVERY

用于加速药物发现的机器人核磁共振光谱仪。其目的是建立一个设施，该设施将使用一个机器人核磁共振仪器来帮助描述药物-蛋白质相互作用的特征，并帮助发现新的药物或农药。重要的是，随着基因组学项目中蛋白质序列的大量新信息的出现，迫切需要加快发现与这些蛋白质结合的配体的速度。这些配体可以提供有用的药物线索或帮助确定新发现的蛋白质的功能。结果将是关于蛋白质结构和功能的新知识，以及潜在的新的生物活性分子。

A ROBOTIC NMR SPECTROMETER FOR ACCELERATED DRUG DISCOVERY. The aim is to establish a facility that will use a robotic NMR instrument to help in the characterisation of drug-protein interactions and in the discovery of new drugs or agrichemicals. The significance is that with the wealth of new information arising on protein sequences from genomics programs there is an urgent need to accelerate the rate of discovery of ligands that bind to these proteins. Such ligands may provide useful drug leads or help in defining the function of newly discovered proteins. The outcomes will be new knowledge on protein structure and function, and potentially, new bio-active molecules.