Molecular analysis of chromatin assembly

“表观遗传学”的一个定义是一种不严格由DNA序列决定的稳定的遗传形式。表观遗传调控是基因组位点对特定转录状态的承诺的基础。表观遗传转录调控的破坏可导致疾病的发展。近年来，人们发现大多数表观遗传调控发生在染色质结构水平。染色质结构调控的一种方式发生在染色质组装水平上，这是真核生物中DNA被包装在组蛋白中的进化保守过程。

One definition of "epigenetics" is a stable form of genetic inheritance that is not strictly determined by DNA sequence. Epigenetic regulation can underlie the commitment of a genomic locus to a specific transcriptional state. The disruption of epigenetic regulation of transcription can lead to disease development. In recent years it has become clear that most epigenetic regulation occurs at the level of chromatin structure. One way chromatin structure is regulated occurs at the level of chromatin assembly, the evolutionarily conserved process in eukaryotes where DNA is packaged within histones.