Upgrade of X-ray diffractometer for small molecules

分子结构的测定在科学特别是化学的发展中起着至关重要的作用。分子结构是深入了解化学的关键，而深入了解化学又是将化学知识转化为造福社会的技术的先决条件。单晶X射线衍射法是确定分子物种结构的最重要的方法。该方法在分子化学领域具有重要意义，也是迄今为止最重要的表征标准方法之一。所需设备将用于维修和升级现有的单晶X射线衍射仪，用于研究和培训高素质人员。该仪器位于萨斯喀彻温省结构科学中心，这是一个中心设施，为萨斯喀彻温大学(S大学)的科学界和萨斯喀彻温大学以外的其他研究人员提供服务。现有的衍射仪过去曾为大约20个研究小组提供服务。对于许多研究项目来说，X射线衍射仪的可用性对他们的研究是必不可少的。这一建议的七名申请者也是如此，他们的研究项目涵盖了从有机金属到(生物)有机和药物化学的广泛领域。

The determination of molecular structures plays a crucial role in the development of science and of chemistry in particular. Molecular structures are keys to a deeper understanding of chemistry, which, in turn, is the prerequisite to transform chemical knowledge into technology for the benefit of society. The method of single-crystal X-ray diffraction is the most important method to determine structures of molecular species. This method is of central importance in the area of molecular chemistry and is one of the most important standard methods of characterization to date. The equipment requested will be used to repair and upgrade an existing single-crystal X-ray diffractometer that will be used for research and training of highly qualified personnel. This instrument is located in the Saskatchewan Structural Sciences Centre (SSSC), which is a central facility that serves the scientific community of the University of Saskatchewan (U of S) and other researchers external to the U of S. The existing diffractometer has served approximately 20 research groups in the past. For many research programs the availability of an X-ray diffractometer is essential for their research. This holds true for the seven applicants of this proposal, whose research programs span a wide field from organometallic-, to (bio)organic-, and medicinal chemistry.