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Control of Reversible Growth Arrest and Survival by the C/EBP Family of Transcription Factors

Control of Reversible Growth Arrest and Survival by the C/EBP Family of Transcription Factors
C/EBP 转录因子家族对可逆生长停滞和存活的控制
批准号:
138265-2012
负责人:
Bédard, André
金额:
$1.89万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2012
资助国家:
加拿大
项目状态:
已结题
起止时间:
2012-01-01 至 2013-12-31

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中文摘要
翻译
当细胞退出细胞周期,进入可逆性生长停滞状态,即G0或静止状态时,激活的信号通路仍然知之甚少。在过去的18个月里,我们已经确定低氧水平(低氧)为在静止的鸡胚胎成纤维细胞(CEF)中诱导生长停滞特异性基因(GAS基因)提供了信号。以p20K Lipocalin基因作为GAS基因的模型,我们鉴定了CHOP-C/EBP?转录因子是一个新的低氧反应因子,控制静止期CEF中GAS基因的表达。
英文摘要
Signaling pathways activated when cells exit the cell cycle and enter a state of reversible growth arrest, known as G0 or quiescence, remain poorly understood. In the last eighteen months, we have determined that low oxygen levels (hypoxia) provide the signal for the induction of growth-arrest specific (gas genes) in quiescent chicken embryo fibroblasts (CEF). Using the p20K lipocalin gene as a model of gas gene, we identified the CHOP-C/EBPß transcription factor as a novel hypoxia-responsive factor controlling the expression of gas genes in quiescent CEF.
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Functional characterization of growth arrest-specific genes in primary fibroblasts
  • 批准号:
    RGPIN-2017-04694
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $8.74万
  • 财政年份:
    2021
  • 负责人:
    Bédard, André
  • 依托单位:
Functional characterization of growth arrest-specific genes in primary fibroblasts
  • 批准号:
    RGPIN-2017-04694
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $4.37万
  • 财政年份:
    2020
  • 负责人:
    Bédard, André
  • 依托单位:
Functional characterization of growth arrest-specific genes in primary fibroblasts
  • 批准号:
    507801-2017
  • 项目类别:
    Discovery Grants Program - Accelerator Supplements
  • 资助金额:
    $2.91万
  • 财政年份:
    2019
  • 负责人:
    Bédard, André
  • 依托单位:
Functional characterization of growth arrest-specific genes in primary fibroblasts
  • 批准号:
    RGPIN-2017-04694
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $4.37万
  • 财政年份:
    2019
  • 负责人:
    Bédard, André
  • 依托单位:
国内基金
海外基金
温敏不育突变体(reversible male sterile)育性转换机制的研究
  • 批准号:
    31770348
  • 项目类别:
    面上项目
  • 资助金额:
    60.0万元
  • 批准年份:
    2017
  • 负责人:
    朱骏
  • 依托单位: