Innate immunity to infectious bronchitis virus infection in chickens

传染性支气管炎（IB）是一种高度传染性的病毒感染，其影响包括北美在内的全球地球仪的鸡操作，增加生产成本。IB控制严重依赖于含有实验室减毒弱病毒的疫苗。 由于两个主要原因，IB的爆发发生在接种疫苗的鸡。首先，减毒疫苗病毒通过鸡群获得致病能力。其次，野外IB病毒的突变对抗疫苗接种施加的压力导致严重的疾病。因此，建立更可持续的鸡IB控制措施势在必行。 潜在的方法之一是使用免疫刺激剂沿着灭活的IB病毒，而不是由弱病毒制成的疫苗，以诱导对暴露的IB病毒的持久抗性。为了建立这一控制手段，我们将建立实验性鸡IB病毒感染模型，以研究呼吸道粘膜的自然抗性机制。然后，我们将确定天然抗性的介质，并使用合适的合成或天然免疫刺激剂来增加共同施用的灭活病毒的有效性。拟议的研究将导致开发新的和可持续的方法来控制鸡IB。

Infectious bronchitis (IB) is a highly contagious viral infection, which impact the chicken operations across the globe including North America, increasing the cost of production. IB control heavily depends on vaccines containing laboratory attenuated weak viruses. For two major reasons, outbreaks of IB arise in vaccinated chickens. Firstly, weakened vaccine virus gains the ability to cause disease by going through the flock. Secondly, mutation of the field IB virus against the pressure imposed by vaccination lead to severe disease. Therefore, it is imperative to establish more sustainable control measures against IB in chickens. One of the potential ways is the use of immune stimulants along with inactivated IB virus, instead of vaccines made of weak viruses, to induce long lasting resistance against exposed IB virus. In order to establish this mean of control, we will establish an experimental IB virus infection model in chickens to study the natural mechanisms of resistance in the respiratory mucosa. Then we will identify mediators of natural resistance and use suitable synthetic or natural immune stimulant to increase the effectiveness of co-administered inactivated viruses. The proposed studies will lead to development of novel and sustainable ways of controlling IB in chickens.