Innate Immunity: From Innate Sensing to Adaptive Responses

摘要 请求为题为“先天免疫：从先天感觉到免疫”的Keystone专题讨论会提供支助。 适应性反应，由吴昊博士，罗素万斯和安德里亚·萨瑟组织。会议将 2023年4月16日至19日在犹他州雪鸟举行。 所有生命领域的生物都进化出了先天免疫系统， 药物和维持体内平衡。然而，人们仍然缺乏基本的理解， 先天免疫系统被激活，以引起保护性反应，以及它如何也可以过度反应，以某些 侮辱，从而造成伤害。本次Keystone研讨会旨在将那些对以下方面感兴趣的人聚集在一起： 各种形式的先天免疫本次会议计划将包括讨论对 先天免疫机制的多样性，先天免疫的深层进化起源， 先天免疫在人类疾病中的作用，以及它在形成适应性免疫反应中不可或缺的作用， 感染和癌症。会议将跨越多个层次的研究，从分子结构到细胞 相互作用，以及有机体生物学和人类病理学。预计，通过汇集这样一个 专家组认为，将有许多机会进行跨学科的互动，以丰富新的 深入了解先天免疫系统，从先天感应到适应性反应。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Innate Immunity: From Innate Sensing to Adaptive Responses, organized by Drs. Hao Wu, Russell Vance and Andrea Ablasser. The conference will be held in Snowbird, Utah from April 16-19, 2023. Living things in all domains of life have evolved innate immune systems to protect against diverse infectious agents and maintain homeostasis. However, there is still a lack of fundamental understanding on how the innate immune system is activated to elicit protective responses, and how it can also overreact to certain insults and thus cause harm. This Keystone Symposia conference aspires to bring together those interested in innate immunity in all its diverse forms. This conference program will include discussion of insights into the diversity of innate immune mechanisms, the deep evolutionary origins of innate immunity, the important roles of innate immunity in human disease, and its indispensable function in shaping adaptive immune responses to infections and cancer. The sessions will span research at multiple levels, from molecular structures to cellular interactions, and to organismal biology and human pathology. It is anticipated that by bringing together such a group of experts, that there will be numerous opportunities for cross-disciplinary interactions to fertilize novel insights into the innate immune system, from innate sensing to adaptive responses.