Innate Immunity: From Innate Sensing to Adaptive Responses

先天免疫：从先天感知到适应性反应

• 批准号: 10608714
• 负责人: TERRY L. SHEPPARD
• 金额: $ 0.8万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-11-01 至 2023-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10608714
• 关键词: Address; Area; Bacteria; Biological Process; Biology; Chronic; Clinic; Collaborations; Communicable Diseases; Educational workshop; Ensure; Fertilization; Future; Homeostasis; Human; Human Pathology; Immunology; Infection; Infectious Agent; Innate Immune System; Invertebrates; Knowledge; Learning; Life; Malignant Neoplasms; Metabolic Diseases; Methodology; Molecular Structure; Natural Immunity; Organism; Outcome; Reaction; Research; Research Activity; Research Personnel; Role; STEM field; Scientist; Shapes; System; Technology; Translating; Utah; Work; adaptive immune response; biological systems; career; clinical practice; human disease; improved; innate immune mechanisms; insight; interest; mouse model; next generation; novel; novel strategies; posters; programs; response; symposium

ABSTRACT Support is requested for a Keystone Symposia conference entitled Innate Immunity: From Innate Sensing to Adaptive Responses, organized by Drs. Hao Wu, Russell Vance and Andrea Ablasser. The conference will be held in Snowbird, Utah from April 16-19, 2023. Living things in all domains of life have evolved innate immune systems to protect against diverse infectious agents and maintain homeostasis. However, there is still a lack of fundamental understanding on how the innate immune system is activated to elicit protective responses, and how it can also overreact to certain insults and thus cause harm. This Keystone Symposia conference aspires to bring together those interested in innate immunity in all its diverse forms. This conference program will include discussion of insights into the diversity of innate immune mechanisms, the deep evolutionary origins of innate immunity, the important roles of innate immunity in human disease, and its indispensable function in shaping adaptive immune responses to infections and cancer. The sessions will span research at multiple levels, from molecular structures to cellular interactions, and to organismal biology and human pathology. It is anticipated that by bringing together such a group of experts, that there will be numerous opportunities for cross-disciplinary interactions to fertilize novel insights into the innate immune system, from innate sensing to adaptive responses.

摘要 请求支持题为《先天免疫：从先天感觉到 适应性反应，由吴浩博士、拉塞尔·万斯博士和安德里亚·阿布拉瑟博士组织。会议将于 2023年4月16日至19日在犹他州雪鸟举行。 生命中所有领域的生物都进化出了先天免疫系统，以抵御不同的传染病 并保持动态平衡。然而，仍然缺乏对如何实现 先天免疫系统被激活以引发保护性反应，以及它是如何对某些特定的 侮辱，从而造成伤害。本次Keystone研讨会致力于将那些有兴趣的人聚集在一起 各种形式的先天免疫力。这一会议计划将包括对 先天免疫机制的多样性，是先天免疫的深层进化起源、重要作用 先天免疫在人类疾病中的作用，及其在形成适应性免疫反应方面不可或缺的功能 感染和癌症。这些会议将跨越多个层面的研究，从分子结构到细胞 相互作用，以及生物生物学和人类病理学。预计通过将这样一个 专家小组认为，将有许多跨学科互动的机会来丰富小说 对先天免疫系统的洞察，从先天感知到适应性反应。