Bioinformatics for comparative and evolutionary genomics

拟议的研究项目侧重于基因组学中的计算方法开发。这些方法所解决的主要生物学问题围绕着作用于不同功能和非功能元素的进化过程之间的相互作用。我将特别关注同源基因家族和真核基因结构的进化。该项目旨在开发新的计算方法来研究剪接体内含子的获得和丢失，或基因的获得和丢失。依靠复杂的数学模型的收益和损失的系统发育背景下，该方法有望揭示选择力量，塑造现代基因组，并有助于功能基因注释。

The proposed research project focuses on computational method development in genomics. The main biological questions adressed by the methods revolve around the interplay between evolutionary processes acting on different functional and non-functional elements. I will in particular focus on the evolution of homolog gene families and of eukaryotic gene structure. The project aims to develop novel computational methods to study the gain and loss of spliceosomal introns, or the gain and loss of genes. Relying on sophisticated mathematical models of gains and losses in a phylogenetic context, the methods are expected to shed light on selection forces that shaped modern genomes, and to aid in functional gene annotations.