Integrated Biosensors and BioMEMS for Bio-Detection Applications

我们的研究计划的目标是产生集成传感器系统的新技术，这将导致超高灵敏度和速度的通用、现场可用传感器的发展。我们的生物传感平台包括灵敏的高通量光学微谐振器筛选阵列和光波导传感器。这些新型的生物传感平台将采用各种现有的和新兴的识别元件，包括噬菌体、噬菌体展示、适体和分子印迹聚合物。我们还专注于将生物传感器集成到芯片实验室系统中，该系统允许自动样品处理（实际分析之前的繁琐步骤），具有高水平的生物防护和最少的处理。完全集成的生物传感平台提供超灵敏和可靠的多分析物检测；它们的微型尺寸（一个带有一次性样品处理芯片的单个便携式设备）允许轻松的现场部署和无处不在的适用性。我们的生物传感器和芯片实验室系统适用于医疗点内外的环境监测、诊断和治疗应用。拟议的五年研究计划分为三个主题：(A)开发用于快速生物样品操作和检测的集成超声芯片实验室，(B)开发光学高通量微谐振器筛选平台（lab-on-a-bead），以及(C)开发基于噬菌体的治疗（治疗和诊断）平台。我们的研究为高素质人才提供多学科培训，并将产生重要的技术诀窍，对加拿大的研发和经济产生积极影响。

The objective of our research program is to generate novel technologies towards integrated sensor systems which will lead to the development of general-purpose, field-usable sensors with ultra-high sensitivity and rapidity. Our biosensing platforms include sensitive high-throughput optical micro-resonator screening array and optical waveguide sensors. These novel biosensing platforms will employ a wide variety of existing and emerging recognition elements including bacteriophages, phage-display, aptamers and molecularly imprinted polymers. We also focus on integrating the biosensors within lab-on-a-chip systems, which allow automatic sample processing (a tedious step prior to the actual analysis) with high level of biocontainment and minimal handling. Fully integrated biosensing platforms offer ultra-sensitive and reliable multi-analyte detection; their miniature size (a single portable device with disposable sample processing chip) allows easy field deployment and ubiquitous applicability. Our biosensors and lab-on-a-chip systems are suitable for use in environmental monitoring, diagnostic and therapeutic applications at and outside point-of-care. The proposed five-year research program is divided into three themes: (A) Development of integrated ultrasonic lab-on-a-chip for rapid biological sample manipulation and detection, (B) Development of optical highthroughput micro-resonator screening platform (lab-on-a-bead), and (C) Development of phage-based theranostic (therapeutics and diagnostics) platforms. Our research provides multidisciplinary training for highly qualified personnel and will generate significant technological know-how, creating a positive impact on Canadian R&D and economy.