课题基金 / 基金详情

Control of Reversible Growth Arrest and Survival by the C/EBP Family of Transcription Factors

Control of Reversible Growth Arrest and Survival by the C/EBP Family of Transcription Factors
C/EBP 转录因子家族对可逆生长停滞和存活的控制
批准号:
138265-2012
负责人:
Bédard, André
金额:
$1.89万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2013
资助国家:
加拿大
项目状态:
已结题
起止时间:
2013-01-01 至 2014-12-31

项目摘要

项目成果

Bédard, André的其他基金

相似基金

相关文献

中文摘要
翻译
当细胞退出细胞周期并进入可逆生长停滞状态(称为G0或静止)时,信号通路被激活,人们对其知之甚少。在过去的18个月里,我们已经确定低氧水平(缺氧)为诱导静止鸡胚成纤维细胞(CEF)的生长停止特异性(气体基因)提供了信号。以p20K脂载蛋白基因作为gas基因的模型,我们发现CHOP-C/EBPß转录因子是一种新的缺氧反应因子,可以控制静止CEF中gas基因的表达。
英文摘要
Signaling pathways activated when cells exit the cell cycle and enter a state of reversible growth arrest, known as G0 or quiescence, remain poorly understood. In the last eighteen months, we have determined that low oxygen levels (hypoxia) provide the signal for the induction of growth-arrest specific (gas genes) in quiescent chicken embryo fibroblasts (CEF). Using the p20K lipocalin gene as a model of gas gene, we identified the CHOP-C/EBPß transcription factor as a novel hypoxia-responsive factor controlling the expression of gas genes in quiescent CEF.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Functional characterization of growth arrest-specific genes in primary fibroblasts
  • 批准号:
    RGPIN-2017-04694
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $8.74万
  • 财政年份:
    2021
  • 负责人:
    Bédard, André
  • 依托单位:
Functional characterization of growth arrest-specific genes in primary fibroblasts
  • 批准号:
    RGPIN-2017-04694
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $4.37万
  • 财政年份:
    2020
  • 负责人:
    Bédard, André
  • 依托单位:
Functional characterization of growth arrest-specific genes in primary fibroblasts
  • 批准号:
    507801-2017
  • 项目类别:
    Discovery Grants Program - Accelerator Supplements
  • 资助金额:
    $2.91万
  • 财政年份:
    2019
  • 负责人:
    Bédard, André
  • 依托单位:
Functional characterization of growth arrest-specific genes in primary fibroblasts
  • 批准号:
    RGPIN-2017-04694
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $4.37万
  • 财政年份:
    2019
  • 负责人:
    Bédard, André
  • 依托单位:
国内基金
海外基金
温敏不育突变体(reversible male sterile)育性转换机制的研究
  • 批准号:
    31770348
  • 项目类别:
    面上项目
  • 资助金额:
    60.0万元
  • 批准年份:
    2017
  • 负责人:
    朱骏
  • 依托单位: