"Z-Selective Metathesis, Alkyne Metathesis, and Deactivation in Metathesis"

烯烃化合作用提供了非常强大的化学方法来组装碳-碳键，这是分子和先进材料的框架。它在2005年获得诺贝尔奖，部分原因是它在减少化学和制药制造中通过经典合成方法产生的废物比例方面具有巨大的潜力。然而，到目前为止，实现这一反应的强大催化剂基本上还没有在工业上使用。问题在于它们的寿命很短，这导致了不经济的过程。我们试图了解为什么这些催化剂很脆弱，以及它们在使用条件下是如何分解的。这样的理解将有力地帮助设计下一代、寿命长的催化剂，并使工业应用成为可能。

Olefin metathesis offers exceptionally powerful chemical methods for assembling carbon-carbon bonds, the frameworks of both molecules and advanced materials. It was recognized with the Nobel Prize in 2005, in part because of its enormous potential to reduce the proportion of waste generated via classical synthetic methods in chemical and pharmaceutical manufacturing. To date, however, the powerful catalysts that enable this reaction are essentially unused in industry. The problem lies in their short lifetimes, which results in uneconomic processes. We seek to understand why these catalysts are vulnerable, and how they decompose under conditions of use. Such understanding would be a powerful aid to designing next-generation, long-lived catalysts, and enabling industrial uptake.