Microbiome Regulation of the Host Mitochondrial Genome

这个项目旨在描述新发现的过程，即栖息在动物肠道中的细菌通过这些过程影响宿主线粒体，线粒体是细胞的动力源。这个项目利用先进的遗传和分子方法，旨在产生关于改善线粒体功能的新知识，并增进我们对新兴微生物组研究领域的理解。预期的结果包括一个新颖和通用的技术平台，在其中设计小分子和益生菌以改善线粒体健康并增强一系列动物的健康。这将通过科学上相关的成果和通过技术进步带来的经济利益提供显著的好处。

This project aims to describe newly discovered processes by which bacteria that reside in the gut of an animal influences host mitochondria, the powerhouses of the cell. Using advanced genetic and molecular methodologies, this project aims to generate new knowledge on improving mitochondrial function as well as advance our understanding of the emerging field of microbiome research. Expected outcomes include a novel and universal technology platform in which to engineer small molecules and probiotics to improve mitochondrial health and enhance fitness in a range of animals. This should provide significant benefits, through both scientifically relevant outcomes and economic benefits through technological advancements.