Nanoparticle-mediated highly efficient microfluidic capture and sorting of rare cells

循环中的肿瘤细胞通过生长的肿瘤进入血液。即使肿瘤很小，CTC也可以存在，因此为癌症的非侵入性早期检测提供了一个有希望的标志物。 我们正在开发一种新的设备，可以分离这些细胞并对其生化状态进行分类。该设备可以帮助使用非侵入性收集的血液样本分析肿瘤，其使用最终可能导致改进的癌症筛查测试的发展。 在这个项目中，我们正在推进CTC分析设备的商业化，通过重新设计它，以适应大批量生产。 我们还将整合一个CTC检测系统，该系统将是用户友好和直接自动化的。 有了这些关键的进展，我们将准备好追求这种设备的商业化。

Circulating tumor cells are shed into the bloodstream by growing tumours. CTCs can be present even when tumours are small and therefore present a promising marker for noninvasive early detection of cancer. We are developing a new device that can isolate these cells and classify their biochemical state. This device may aid in the analysis of tumours using a blood sample collected non-invasively, and its use could eventually lead to the development of improved cancer screening tests. In this project, we are advancing a CTC analysis device to commercialization by re-engineering it to be amenable to high volume manufacturing. We will also integrate a CTC detection system that will be user-friendly and straightforward to automate. With these key advances in hand, we will be ready to pursue commercialization of this device.