Function of cytochrome P450 enzymes in aquatic species

细胞色素P450酶对激素的产生和代谢具有重要作用。环磷酰胺对防御也至关重要；它们能代谢环境污染物和大多数药物。CYP1酶代谢雌二醇、多环芳烃和多环芳胺；对雌激素调节和防御都很重要。来自几个水生物种的完整基因组已经提供了关于动物中CYP基因的发育和多样性的细节。然而，我们不知道新型CYP酶的功能，也不能基于哺乳动物的研究来确定其功能。由于缺乏对CYP功能的通用测定，测定功能受到限制。这项研究的目的是确定新的CYP基因在水生物种中的功能，重点是CYP 1家族。

Cytochrome P450 enzymes (CYPs) are crucial for the production and metabolism of hormones. CYPs are also critical for defense; they metabolize environmental contaminants and most drugs. CYP1 enzymes metabolize estradiol, polycyclic aromatic hydrocarbons and polycylic aromatic amines; important for both estrogen regulation and defense. The complete genomes from several aquatic species has provided details regarding the development and diversity of CYP genes in animals. Yet, we don't know the function of the novel CYP enzymes and function cannot be determined based on mammalian studies. Determining function is limited by the lack of a general assay for CYP function. The objectives of the research are to determine function of novel CYP genes in aquatic species, focusing on the CYP 1 family.