Characterization of a glycoprotein entry complex from a novel orthomyxovirus

传染性鲑鱼贫血病毒（ISAV）是一种引起大西洋养殖鲑鱼严重贫血的重要新兴疾病。这种疾病可以在整个受感染的农场缓慢进展，死亡率可能接近100%。该病毒于1984年首次在挪威被发现，但在过去的25年里，ISAV在加拿大，美国，和世界上其他国家。2012年7月，纽芬兰确认爆发疫情，导致45万条养殖鲑鱼被销毁。该病毒已造成重大经济损失，并对鲑鱼养殖的可行性构成重大威胁。目前，对其病毒生命周期知之甚少。迫切需要进一步的研究来了解这种病毒如何进入其鲑鱼宿主的基本生物学。

Infectious salmon anaemia virus (ISAV) is a significant emerging disease of Atlantic farmed salmon that causes severe anemia. The disease can progress slowly throughout an infected farm, and mortality rates may approach 100%. The virus was first identified in Norway in 1984, but over the last 25 years ISAV has caused major disease outbreaks in Canada, U.S., and other countries around the world. In July 2012, a confirmed outbreak in Newfoundland prompted the destruction of 450,000 farmed salmon. The virus has caused major economic losses and is a major threat to the viability of salmon farming. Currently, very little is known about its viral lifecycle. Additional studies are urgently needed to understand the basic biology of how this virus enters its salmon host.