Pre-clinical evaluation of the efficacy of combined THC and CBDA to treat nausea in veterinary medicine

几千年来，大麻一直被用来治疗恶心和呕吐。事实上，这种症状是第一个获得批准的医用大麻处方。大麻中的主要精神活性成分是四氢大麻二酚(THC)，它具有抗恶心和止吐的特性。然而，最近的研究表明，大麻中的非精神活性化合物大麻二酚(CBD)和大麻二酸(CBDA)也可以减少恶心和呕吐。事实上，CBDA在减少恶心和呕吐方面的效力是CBD的1000倍，但没有精神运动作用。CBDA是CBD的前体，在工厂加热前发现。虽然在大麻植物中发现的60多种大麻类化合物中的一些已经单独进行了测试，但关于这些化合物组合对恶心和呕吐的影响的研究很少。在这里，我们建议评估THC：CBDA剂量的不同组合比任何一种单独使用更有效地减少恶心的潜力。这些实验的结果将提供

Cannabis has been used to treat nausea and vomiting for thousands of years. Indeed, this symptom was the first to receive approval for medical marijuana prescriptions. The primary psychoactive ingredient in cannabis is tetrahydrocannabidiol (THC) which has anti-nausea and anti-emetic properties. However, recently, research has shown that the non-psychoactive compounds in cannabis cannabidiol (CBD) and cannabidiolic acid (CBDA) also reduce nausea and vomiting. Indeed, CBDA is 1000 times more potent in reducing nausea and vomiting than CBD, but has no psychomotor effects. CBDA is the precursor to CBD that is found in the plant before it is heated. Although some of the over 60 cannabinoid compounds found in the cannabis plant have been tested alone, there has been very little research on the effects of combinations of these compounds on nausea and vomiting. Here we propose to evaluate the potential of various combinations of THC:CBDA doses to more effectively reduce nausea than either agent on its own. The results of these experiments will provide