Synthesis and scale-up of enantiopure pharmaceuticals, TiO2 nanotubes and zeolitic nanomaterials

拟议的研究计划的目标是合成和扩大一系列工业上重要的创新纳米材料的生产规模，包括活性药物成分、对映纯药物、光催化剂、超疏水颗粒/表面和沸石样纳米材料。将使用多尺度工程方法来解开原子和分子水平上的潜在现象，并使用过程工程和控制原理来高效大规模生产新的纳米材料。直接结晶法和非对映体盐结晶法将分别用于对映体分离具有药用意义的聚合体和外消旋体化合物。磁性氧化铁将作为枢纽与有机连接体一起合成沸石咪唑酸框架（ZIFs），以装载药物进行控制和靶向药物释放。采用阳极氧化法制备了结构良好的TiO2纳米管阵列和Fe、C、N；有机染料;而ZIF纳米粒子将被添加到它们中，以降低它们的带隙能量并提高它们对可见光的光敏性。这些纳米材料将用于氧化污染物、太阳能电池、制氢和制备超疏水表面。后者需要氟化合物对纳米TiO2进行功能化。这些功能化纳米材料的一个主要应用是有效分离水-油（水/有机）乳剂和混合物，这将在油砂加工、矿山尾矿清理和溢油中有潜在的应用。本文将利用微波和超声辅助组合的方法合成一系列金属有机骨架（MOF）和zno纳米材料。我们实验室提出的混合工艺已经产生了高达传统溶剂热工艺100倍的产量，并且可以彻底改变这些材料的生产，并强烈影响环境保护（二氧化碳捕获和CO的低温氧化），氢储存和药物输送系统。

The objectives of the proposed research program are to synthesize and scale up the production of a series of industrially significant innovative nanomaterials ranging from the active pharmaceutical ingredients, enantiopure pharmaceuticals, photocatalysts, superhyrophobic particles/surfaces, and zeolitic like nanomaterials. A multi-scale engineering approach will be used to unravel the underlying phenomena at the atomic and molecular levels and to use process engineering and controls principles for efficient large scale production of the new nanomaterials. Direct crystallization and diasteremeric salts crystallization will be used for the enantioseparation of pharmaceutically significant conglomerates and racemic compounds, respectively. Magnetic iron oxide will be used as a hub along with organic linkers to synthesize zeolitic imidazolate frameworks (ZIFs) to load pharmaceuticals for controlled and targeted drug release. Using anodization, well-formed nano-tube arrays of TiO2 will be synthesized and Fe, C, N; organic dyes; and ZIF nanoparticles will be added to them to reduce their bandgap energy and improve their photosensitivity to visible light. These nanomaterials will be used for oxidation of pollutants, in solar cells, for hydrogen production, and to prepare superhydrophobic surfaces. The latter requires functionalization of the nano TiO2 by fluorine compounds. A major application of these functionalized nanmomaterials is for the effective separation of water oil (aqueous/organic) emulsions and mixtures which will have potential applications in oilsand processing, cleaning up of the tailings in the mining sites and oil spills. A series of metal organic framework (MOF) and ZIF nanomaterials will be synthesized using an assisted combined microwave and ultrasound approach. The proposed hybrid process in our lab has already resulted in yields as high as 100 times of the conventional solvothermal processes, and can revolutionize production of these materials and strongly affect the environmental protection (CO2 capture and cold temperature oxidation of CO), hydrogen storage and drug delivery systems.