Metal mediated and catalyzed organic synthetic methods

本研究的目的是开发和理解一系列由过渡金属络合物或过渡金属络合物或主族化合物催化的新型有机化学反应。目标包括开发传统有机化学过程通常不容易完成的碳-碳键形成反应类型(即，相对于大多数有机化合物，反应性模式是相反的)，以及制备和使用如果没有金属单元就不可能正常存在的化合物。特别是，所提出的铟、铑和铱催化的烯丙化反应，与其他催化反应相结合，被设计为提供这种反转反应模式的催化方法。建议的烷基二钴络合物的设计是为了使如果没有钴就无法分离的化合物的使用成为可能。 所研究的反应的最终目标是发展化学，使其能够用于合成重要的有机分子，如具有潜在的抗癌性能、抗白血病性能、抗细菌或昆虫拒食活性的化合物。在许多情况下，有机化合物只是具有有趣的结构，而在其他情况下，所制备的化合物是为了解决基本问题而设计的，例如是什么使化合物稳定(或不稳定)。

The objective of the proposed research is to develop and understand a series of novel organic chemical reactions mediated by transition metal complexes or catalyzed by either transition metal complexes or main group compounds. The goals include the development of types of carbon-carbon bond forming reactions not normally readily accomplished by traditional organic chemical processes (i.e., the pattern of reactivity is inverted relative to most organic compounds), and to prepare and use compounds that could not normally exist if it were not for the presence of the metal unit. In particular the proposed indium, rhodium, and iridium catalyzed allylation reactions, in conjunction with other catalytic reactions, are designed for being catalytic methods of giving this inverted pattern of reactivity. The proposed alkynedicobalt complexes are designed to make possible the use of compounds that could not be isolated if not for the cobalt. The ultimate goal for the reactions investigated is to develop the chemistry to the point where it can be used in the synthesis of organic molecules of importance, such as compounds that have potential anti-cancer properties, antileukemic properties, antibacterial or insect antifeedant activity. In many cases, the organic compounds simply have interesting structures, and in other cases the prepared compounds are designed to address fundamental questions, such as what makes a compound stable (or unstable).