Impact of TRPV6 ligation on colonic epithelial cell-dendritic cell crosstalk during induction of an innate immune response

最近的研究结果已经确定了肠道上皮细胞之间交流的重要性 和树突细胞，其是一种白色血细胞，用于启动和调节宿主免疫应答。 可能参与这些重要相互作用的分子之一是钙通道，称为 TRPV 6，具有信号传导特性，由结肠上皮细胞表达。Soricimed Biumarma SBI公司已经开发了一个结合并改变TRPV 6活性的小蛋白家族， 感兴趣的是确定这些蛋白质与结肠上皮细胞的结合是否会影响附近细胞的能力。 树突状细胞对细菌“危险信号”作出反应。在这个合作研究项目中，我们将 确定TRPV 6-选择性肽相互作用对树突状细胞产生各种 化学信使对存在于细菌DNA中的CpG寡脱氧核苷酸作出反应。这种合作 代表了一个独特的机会，探索树突状细胞对“危险信号”的反应， 肠上皮细胞的TRPV 6钙通道功能改变。

Recent findings have established the importance of communication between the epithelial cells that line the gut and dendritic cells, which are a type of white blood cell, for initiating and regulating host immune responses. One of the molecules that might be involved in these important interactions is a calcium channel, termed TRPV6, that has signaling properties and is expressed by epithelial cells in the colon. Soricimed Biopharma Incorporated (SBI) has developed a family of small proteins that bind to and alter the activity of TRPV6, and is interested to determine whether binding of these proteins to colonic epithelial cells affects the ability of nearby dendritic cells to response to a bacterial "danger signal". In this collaborative research project, we will determine the effect of TRPV6-selective peptide interactions on the ability of dendritic cells to produce various chemical messengers response to CpG oligodeoxynucleotide present in the DNA of bacteria. This collaboration represents a unique opportunity to explore the response of dendritic cells to "danger signals" in the context of altered TRPV6 calcium channel function of gut epithelial cells.