Synthesis of next-generation UV indicators for sun safety applications

Suncayr目前正在研发一种基于入射紫外线辐射的颜色变化指示器，该指示器将告诉用户他们的防晒霜何时不再有效。Suncayr目前使用的是一种对紫外线有反应的分子，当暴露在阳光的紫外线辐射下时，这种分子会从无色变成紫色，这向用户表明他们正在受到有害的紫外线的影响。 Suncayr正在寻找其原始化合物的下一代衍生品，根据到达皮肤的入射紫外线辐射量的不同，这些衍生品将显示不同的响应系数。例如，这种分子可能足够可调，使Suncayr能够开发出在不同SPF保护级别(如SPF 2、4或8)下显示基于颜色的警告指示的产品。如果紫外光指示剂化合物能够被衍生以允许这种不同的性质，它将导致可为不同终端用户定制的改进指示剂。 Suncayr缺乏合成专业知识和设备，无法对其紫外线响应性染料进行必要的更改。通过与墨菲实验室的合作，他们将获得进行这项基础研究所需的人员、专业知识、设施和设备。墨菲实验室将使用分子建模和化学合成的互补策略来指导他们的工作，这将生成一个小型衍生库，供Suncayr测试。有希望的候选者将被更大规模地合成，为森卡伊尔提供足够的材料来进行材料性能分析。

Suncayr is currently in the research and development phase of creating a colour change indicator based on incident UV radiation that will tell the user when their sunscreen is no longer effective. Suncayr is currently using a UV responsive molecule that will change from colourless to purple when exposed to the UV radiation of sunlight, indicating to the user that they are being subject to harmful UV rays. Suncayr is looking for next-generation derivatives of their original compound that will exhibit different response factors depending on the amount of incident UV radiation reaching the skin. For example, this molecule might be sufficiently tunable to enable Suncayr to develop products that will exhibit a colour-based warning indication at differing SPF protection levels (such as SPF 2, 4 or 8). If the UV indicator compound can be derivatized to permit such differing properties, it will result in improved indicators that are customizable for different end users. Suncayr lacks the synthetic expertise and facility to make the necessary alterations to their UV responsive dye. By collaborating with the Murphy laboratory, they will gain access to the required personnel, expertise, facilities and equipment necessary to undertake this fundamental research. The Murphy lab will use the complementary strategies of molecular modeling and chemical synthesis to guide their work, which will generate a small library of derivatives for Suncayr to test. Promising candidates will be synthesized on larger scale to provide Suncayr with sufficient materials to carry out their materials performance analyses.