Mobility, organization and signalling of immune cell surface receptors
Mobility, organization and signalling of immune cell surface receptors
批准号:
RGPIN-2015-04611
负责人:
Coombs, Daniel
金额:
$3.79万
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2015
资助国家:
加拿大
项目状态:
已结题
起止时间:
2015-01-01 至 2016-12-31
中文摘要
B细胞是适应性免疫应答的重要组成部分。在体内,B细胞可以在将特异性抗原与其B细胞受体(BCR)结合后变得活化(导致增殖和分泌结合并中和入侵病原体的抗体)。已知B细胞表面受体在抗原信号检测期间在空间上组织它们自己。因此,为了获得对B细胞活化的正确理解,我们需要研究表面分子如BCR的运动,并将它们的运动与细胞内导致细胞活化的生化反应联系起来。
英文摘要
B cells are an essential part of the adaptive immune response. In vivo, B cells can become activated (leading to proliferation and secretion of antibodies that bind to and neutralize invading pathogens) after binding specific antigens with their B cell receptors (BCR). B cell surface receptors are known to spatially organize themselves during antigenic signal detection. Therefore, in order to obtain a proper understanding of B cell activation, we need to study the motion of surface molecules such as BCR and relate their motion to the biochemical reactions within the cell that lead to cell activation.
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Super-resolution imaging, single cell analysis, and modelling approaches applied to the study of immune cell signaling and behaviour
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批准号:RGPIN-2020-04820
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项目类别:Discovery Grants Program - Individual
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资助金额:$5.03万
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财政年份:2022
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负责人:Coombs, Daniel
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依托单位:
Super-resolution imaging, single cell analysis, and modelling approaches applied to the study of immune cell signaling and behaviour
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批准号:RGPIN-2020-04820
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项目类别:Discovery Grants Program - Individual
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资助金额:$5.03万
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财政年份:2021
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负责人:Coombs, Daniel
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依托单位:
Super-resolution imaging, single cell analysis, and modelling approaches applied to the study of immune cell signaling and behaviour
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批准号:RGPIN-2020-04820
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项目类别:Discovery Grants Program - Individual
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资助金额:$5.03万
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财政年份:2020
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负责人:Coombs, Daniel
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依托单位:
Mobility, organization and signalling of immune cell surface receptors
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批准号:RGPIN-2015-04611
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.79万
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财政年份:2019
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负责人:Coombs, Daniel
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依托单位:
Mobility, organization and signalling of immune cell surface receptors
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批准号:RGPIN-2015-04611
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.79万
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财政年份:2018
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负责人:Coombs, Daniel
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依托单位:
Mobility, organization and signalling of immune cell surface receptors
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批准号:RGPIN-2015-04611
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.79万
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财政年份:2017
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负责人:Coombs, Daniel
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依托单位:
Mobility, organization and signalling of immune cell surface receptors
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批准号:RGPIN-2015-04611
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.79万
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财政年份:2016
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负责人:Coombs, Daniel
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依托单位:
Probing the spatiotemporal dynamics of immune cell surface receptors
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批准号:288180-2009
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项目类别:Discovery Grants Program - Individual
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资助金额:$4.92万
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财政年份:2013
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负责人:Coombs, Daniel
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依托单位:
Probing the spatiotemporal dynamics of immune cell surface receptors
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批准号:288180-2009
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项目类别:Discovery Grants Program - Individual
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资助金额:$4.92万
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财政年份:2012
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负责人:Coombs, Daniel
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依托单位:
Probing the spatiotemporal dynamics of immune cell surface receptors
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批准号:288180-2009
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项目类别:Discovery Grants Program - Individual
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资助金额:$4.92万
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财政年份:2011
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负责人:Coombs, Daniel
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依托单位:
Probing the spatiotemporal dynamics of immune cell surface receptors
-
批准号:288180-2009
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$4.92万
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财政年份:2010
-
负责人:Coombs, Daniel
-
依托单位:
Probing the spatiotemporal dynamics of immune cell surface receptors
-
批准号:288180-2009
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$4.92万
-
财政年份:2009
-
负责人:Coombs, Daniel
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依托单位:
mathematical modeling applied to cellular and sub-cellular processes
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批准号:288180-2004
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项目类别:Discovery Grants Program - Individual
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资助金额:$1.02万
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财政年份:2008
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负责人:Coombs, Daniel
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依托单位:
mathematical modeling applied to cellular and sub-cellular processes
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批准号:288180-2004
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$1.02万
-
财政年份:2007
-
负责人:Coombs, Daniel
-
依托单位:
mathematical modeling applied to cellular and sub-cellular processes
-
批准号:288180-2004
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$1.02万
-
财政年份:2006
-
负责人:Coombs, Daniel
-
依托单位:
mathematical modeling applied to cellular and sub-cellular processes
-
批准号:288180-2004
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$1.02万
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财政年份:2005
-
负责人:Coombs, Daniel
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依托单位:
mathematical modeling applied to cellular and sub-cellular processes
-
批准号:288180-2004
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$1.02万
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财政年份:2004
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负责人:Coombs, Daniel
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依托单位:
国内基金
海外基金
功能有机配体新颖设计与有机金属超分子导向组装
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批准号:20772152
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项目类别:面上项目
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资助金额:28.0万元
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批准年份:2007
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负责人:于澍燕
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依托单位: