Novel antibiotics for treatment of bovine mastitis / Nouveaux antibiotiques pour le traitement de la mammite bovine

最近，我们的研究发现了一种针对细菌的新的抗生素靶点。这个新靶点是一种具有调节功能的RNA分子(鸟嘌呤核糖开关)，显然对引起动物感染的某些细菌是必不可少的。我们还鉴定了一种小的类药物分子，能够结合鸟嘌呤核糖开关，阻止必要基因的表达，从而发挥后续的杀菌作用。我们进一步证明了该化合物的抗菌活性在实验性治疗金黄色葡萄球菌乳房内感染(乳房炎)在小鼠和奶牛。在礼来加拿大公司及其动物健康部门(Elanco)的帮助下，拟议的研发项目旨在优化用于乳制品行业的兽用新型抗生素。

Recently, our research led to the discovery of a new antibiotic target for bacteria. This new target is an RNA molecule with a regulatory function (a guanine riboswitch) apparently essential to certain bacteria causing infections in animals. We also identified a small drug-like molecule able to bind the guanine riboswitch and prevent expression of essential genes with subsequent bactericidal action. We further demonstrated the antibacterial activity of this compound in experimental therapies for Staphylococcus aureus intramammary infections (mastitis) in both mice and cows. With the help of Lilly Canada, Inc., and its animal health component (Elanco), the proposed R&D Project aims at optimizing the novel antibiotic for veterinary use in the dairy industry.