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Studying the role of DNA damage induced RNA in the molecular mechanisms promoting homologous recombination in mammalian cells

Studying the role of DNA damage induced RNA in the molecular mechanisms promoting homologous recombination in mammalian cells
研究DNA损伤诱导的RNA在促进哺乳动物细胞同源重组的分子机制中的作用
批准号:
345110
负责人:
Hendzel Michael J
金额:
$54.58万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2016
资助国家:
加拿大
项目状态:
已结题
起止时间:
2016-03-01 至 2021-03-01

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中文摘要
翻译
最近发现,当我们的DNA被DNA双链断裂的形成所破坏时,这种情况在我们的每个细胞中每天发生大约10次,小rna就会从受损的部位产生。我们相信这些新发现的rna
英文摘要
It has recently been found that when our DNA is damaged by the formation of a DNA double-strand break, which happens about 10 times/cell/day in each of our cells, small RNAs are generated from the damaged site. We believe that these newly discovered RNAs
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Canada Research Chair - Tier 1
  • 批准号:
    454008
  • 项目类别:
  • 资助金额:
    $101.99万
  • 财政年份:
    2021
  • 负责人:
    Hendzel Michael J
  • 依托单位:
Structure-function relationships at DNA double-strand break repair centers
  • 批准号:
    389213
  • 项目类别:
    Operating Grants
  • 资助金额:
    $61.02万
  • 财政年份:
    2018
  • 负责人:
    Hendzel Michael J
  • 依托单位:
Dissecting the signalling functions of polycomb-mediated ubiquitylation in DNA double-strand break repair
  • 批准号:
    239080
  • 项目类别:
    Operating Grants
  • 资助金额:
    $56.0万
  • 财政年份:
    2011
  • 负责人:
    Hendzel Michael J
  • 依托单位:
海外基金