An integrative approach to stress physiology in fish

我的研究计划的长期目标是了解鱼类的生理压力。大多数动物，包括鱼类，经常面临威胁其体内平衡的环境挑战。一系列行为、神经内分泌和细胞事件的协调启动，统称为应激反应，使动物能够对这些应激源作出反应。尽管应激反应对个体和群体的生存和健康具有重要意义，但我们对应激反应如何被调节并与其他生理系统相结合的了解仍然有限，特别是在慢性应激下。此外，压力生理学领域正变得越来越复杂，因为越来越多的证据表明，早期生活中的逆境和压力在塑造下一代的压力生理学和行为方面的代际影响。

The long-term objective of my research program is to understand the physiology of stress in fish. Most animals, including fish, regularly face environmental challenges that threaten their homeostasis. The initiation of a coordinated suite of behavioural, neuroendocrine and cellular events, collectively termed a stress response, allows the animal to respond to such stressors. Despite the importance of stress responses to the survival and fitness of individuals and populations, our knowledge of how they are regulated and integrated with other physiological systems remains limited, particularly during chronic stress. Moreover, the field of stress physiology is becoming more complex as evidence accrues for early life adversity and intergenerational effects of stress in shaping the stress physiology and behaviour of the next generation.