Gut Based Modulators of Metabolism

尽管有大量证据表明肠道微生物组影响代谢，但我们对差异肠道微生物群促进代谢的机制的理解是不完整的。在这方面，最近的研究表明，宿主和微生物群参与了几种复杂的相互作用，导致所谓的“宿主-微生物群代谢轴”。这些代谢轴导致微生物组和宿主基因组对底物的组合代谢，例如胆汁酸、胆碱和蛋白质的产生。

Despite an abundance of evidence showing the gut microbiome to influence metabolism, our understanding of the mechanisms by which differential gut microbiota contribute to metabolism is incomplete. In this respect, recent studies have revealed that the host and the microbiota are involved in several complex interactions resulting in so-called “host-microbiome metabolic axes”. These metabolic axes result in the combinatorial metabolism of substrates by the microbiome and host genome, exemplified by the production of bile acids, choline