To B-E or not to B-E? Developing New Boranes and Boration Reactions

硼元素（B-E，其中E = H、B、Si等）键与不饱和化合物的加成构成了有机合成中一类非常重要的反应，用于生产用于制药和农业工业的新化合物。B-E的反应，其中E是较重的主族元素（E =硅、锗等），通常产生有机双金属化合物，其是高度通用的结构单元，否则难以合成。考虑到在这一领域的兴趣强度，令人惊讶的是，关于含有单个B-E键的化合物的类似加成化学，其中E是硫（S）、硒（Se）或磷（P），相对知之甚少。为了解决硼化学中的这种限制，本提案将集中于扩展相对未知的B-E（E = P，S，Se）化合物的范围和化学性质。例如，我们最近报道了一种新的膦基硼酸酯（Ph

The addition of boron-element (B-E, where E = H, B, Si, etc) bonds to unsaturated compounds constitutes a family of remarkably important reactions in organic synthesis for the production of new compounds for the pharmaceutical and agricultural industries. Reactions of B-E where E is a heavier main group elements (E = silicon, germanium, etc) usually result in organodimetalloid compounds which are highly versatile building blocks that are otherwise difficult to synthesize. Given the intensity of interest in this area it is somewhat surprising that relatively little is known about the analogous addition chemistry of compounds containing single B-E bonds where E is either sulfur (S), selenium (Se), or phosphorus (P). To address this limitation in boron chemistry, this proposal will focus on expanding the scope and chemistry of relatively unknown B-E (E = P, S, Se) compounds. For instance, we have recently reported a new phosphinoboronate ester (Ph