Analytical methods and analysis of in vivo toxicology of nanoparticles derived from the papaya-mosaic virus.

Folia Biotech是一家临床阶段的纳米医学公司，致力于使用来自木瓜花叶病毒的纳米颗粒进行免疫治疗。在其平台技术的临床验证过程中，他们需要关于其主要产品的血液循环特征和生物分布的进一步信息。该提案将分为两部分：1）建立一种稳健的标记方法，可以跟踪复杂生物样品中的纳米颗粒; 2）评估其专有技术的循环和生物分布特征。总之，这些目标将使Folia获得必要的方法，以进一步了解他们的纳米颗粒如何与生物环境相互作用。这个项目将提供技术知识和基本的毒理学理解。这将围绕专有技术创造价值，并培养制药公司的合作兴趣。参与该项目的学术实验室在纳米颗粒的标记和循环概况的评估方面具有公认的卓越性。通过推进可用于疫苗接种和免疫治疗的纳米医学技术的发展，该项目将为加拿大创造价值，并有助于培养高素质的人才。

Folia Biotech is a clinical-stage nanomedicine company working in the field of immunotherapy usingnanoparticles derived from papaya mosaic virus. En route toward clinical validation of their platformtechnology, they require further information on the blood circulation profile and biodistribution of their leadproduct.This proposal will be divided into two parts: 1) establishing a robust labeling method allowing tracking of theirnanoparticles in complex biological samples and 2) evaluating the circulation and biodistribution profiles oftheir proprietary technology. Together, these objectives will allow Folia to acquire the methods necessary tofurther understand how their nanoparticle interact with biological environments. This project will offertechnical knowledge and fundamental toxicology understanding. This will create value surrounding theproprietary technology, and foster the interest of pharmaceutical companies for collaborations.The academic lab involved in this project possesses accredited excellence in the labelling of nanoparticles andthe evaluation of their circulation profiles. By advancing the development of a nanomedicine technology thatcan be used for vaccination and immunotherapy, this project will create value for Canada, and contribute to thetraining of highly qualified personnel.