Development of an inexpensive paper spray mass spectrometry screening assay for fentanyl and other opioid analogs

本项目的目的是开发一种低成本的快速筛查方法，适用于复杂样品中阿片类药物和其他药物类似物(如芬太尼及其衍生物)的检测和鉴定。这项研究的具体目标是开发一种新技术，用于实施减少危害战略，以减少街头毒品中日益常见的危险药物鸡尾酒造成的生命损失。将采用纸喷雾质谱仪技术，将小纸条作为采样装置和将样品直接引入质谱仪的平台。这种直接质谱学方法消除了复杂样品处理的需要，并在大约一分钟内为小样品提供了明确和定量的化学信息。LifeLabs是该项目的优秀合作伙伴，他们致力于改进不列颠哥伦比亚省(和加拿大)的药物筛选方法，这将确保我们研究的快速未来发展和实施。

The aim of this project is to develop a low cost rapid screening assay suitable for the detection andidentification of opioid and other drug analogs (e.g. fentanyl and its derivatives) in complex samples. Theresearch is specifically targeted at developing a new technology for implementation in harm reductionstrategies, in order to reduce loss of life from dangerous drug cocktails that are increasingly common in streetdrugs. The technique of paper spray mass spectrometry will be employed, whereby small paper strips serve asboth the sampling device and the platform for introducing the sample directly to a mass spectrometer. Thisdirect mass spectrometry approach removes the need for complex sample handling, and provides definitive andquantitative chemical information for small samples in approximately one minute. LifeLabs is an excellentpartner for this project, and their commitment to improving drug screening approaches in British Columbia(and Canada) will ensure the rapid future development and implementation of our research.