Simultaneous determination of compounds in cannabis by liquid chromatography tandem mass spectrometry

2018年7月，加拿大联邦政府将为娱乐目的使用大麻合法化。因此，大麻生产商有责任提供清洁和安全的产品。众所周知，吸烟的植物材料，如烟草和含有杀虫剂的大麻产品，可能会产生复杂的化合物混合物，其中许多化合物的毒性比材料中最初存在的化合物更大。针对这一问题，加拿大卫生部承认，必须对供人类消费的产品进行一系列化学品的测量，以表明它们含有已知对最终用户健康有害的不可测量的化学物质。虽然娱乐用大麻中需要测试的化合物的最终目标清单尚未最后确定；杀虫剂尤其如此，但官方分析化学家协会(AOAC)最近与加拿大卫生部联合成立了一个大麻专家工作组来解决这一问题。目前，用于医疗目的的样本需要测试一系列有机化合物，包括大麻类化合物、真菌毒素、萜类化合物和杀虫剂，但只有一组杀虫剂化学物质需要由第三方实验室进行测试。因此，Delta9 Biotech希望能够在内部对其他非农药进行一些分析，以降低其样本分析的总体成本。因此，马尼托巴大学的实验室将开发一种统一的单一分析方法，使用液相色谱串联质谱仪来测量干燥植物材料中的大麻类化合物、萜烯和真菌毒素。

In July 2018, the Federal Government of Canada is set to legalize the use of cannabis for recreational purposes.It is incumbent therefore for cannabis producers to make available products that are clean and safe. It iswell-known that smoking of plant material such as tobacco and cannabis products containing pesticides canyield complex mixtures of compounds, many of which are more toxic than the compounds initially present inthe material. In response to this, Health Canada has acknowledged the importance of measuring products forhuman consumption for a suite of chemicals to show that they contain non-measurable amounts of chemicalsthat are known to be detrimental to the health of the end-user. While a definitive target listing of compounds tobe tested in recreational cannabis has yet to be finalized; this is especially true for the pesticides, theAssociation of Official Analytical Chemists (AOAC) recently established a Cannabis Expert Working Group inconjunction with Health Canada to address this issue. Presently, samples to be used for medical purposes needto be tested for a suite of organic compounds including cannabinoids, mycotoxins, terpenes and pesticides.However, only the pesticides suite of chemicals need to be measured by a third part laboratory. As such, Delta9 Biotech would like to be able to perform some of the analyses of other non-pesticides in-house to reduce theoverall cost of their sample analyses. The laboratory at University of Manitoba will therefore develop a unifiedsingle analytical method to measure cannabinoids, terpenes and mycotoxins in dried plant material using liquidchromatography tandem mass spectrometry.