Identification and environmental fate of novel halogenated polycyclic aromatic compounds in Canada's Oil Sands Region
加拿大油砂地区新型卤代多环芳香族化合物的鉴定和环境归趋
基本信息
- 批准号:RGPIN-2019-05354
- 负责人:
- 金额:$ 2.11万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2020
- 资助国家:加拿大
- 起止时间:2020-01-01 至 2021-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The Alberta Oil Sands (AOS) is the world's third largest reserve
of crude oil with an estimated 165 billion barrels of oil recoverable given
current technologies. The region contains naturally occurring mixtures of crude
bitumen, sand, clay, ultrafine mineral solids and
water that are rich in a soup of organic compounds the most notable of which
are the polycyclic aromatic compounds (PACs). Because of their historical
legacy, federal monitoring activities in Canada have focused on the polycyclic
aromatic hydrocarbons (PAHs) and their alkylated analogs. However, it is known that the AOS region was once covered by sea water
millions of years ago, which would have contained high concentrations of
chloride and bromide ions. During the oil sand formation, the elevated
pressures and temperatures of diagenesis and catagenesis combined with the
catalytic activation of halides formed with abundant crustal elements Al and Fe created an environment conducive to organohalogen
formation. We hypothesize that halogenated PACs would be detectable in
biological samples from the AOS region. The overarching aim of the research program described here is to develop novel analytical techniques using state-of-the-art instrumentation to unearth new
halogenated PAC (HPACs) in environmental samples from the AOS region. This is important because these compounds have not been identified before in the AOS region and there is a potential that these compounds could be more harmful to wildlife than ones not containing halogen atoms. Chlorine and bromine containing PACs
and their alkylated derivatives will be the focus of this student-led research
program. The new compounds identify in biological samples will drive the second major
component of this research program. Specifically, we will examine how susceptible these compounds are to metabolism using a fish liver microsomal bioassay. Commercially
available standards will be used as substrate to understand the metabolic
conversion of these compounds to more polar metabolites. In addition to
understanding how quickly they metabolize, my HQP team will identify the metabolites formed during the incubation bioassay. The identification of HPACs in wildlife from the AOS region and the metabolites formed in fish will lead to
future research activities on the persistence, bioaccumulation and toxicities
of these compounds that our group (and others) will explore.
阿尔伯塔油砂(AOS)是世界第三大储量
原油产量估计为1650亿桶,
目前的技术。该地区含有天然存在的原油混合物,
沥青、沙子、粘土、超细矿物固体和
富含有机化合物的汤,其中最值得注意的是
多环芳香族化合物(PACs)。因自己的历史
加拿大联邦监测活动的重点是多环
芳烃(PAH)及其烷基化类似物。然而,据了解,AOS地区曾经被海水覆盖
数百万年前,那里可能含有高浓度的
氯离子和溴离子。在油砂形成过程中,
压力和温度的成岩作用和退成作用,
大量地壳元素Al和Fe形成的卤化物的催化活化创造了有利于有机卤素的环境
阵我们假设卤代PAC可以在
AOS地区的生物样本 这里所描述的研究计划的总体目标是开发新的分析技术,使用最先进的仪器来挖掘新的
卤化PAC(HPAC)的环境样品从AOS地区。 这一点很重要,因为这些化合物以前在AOS地区没有被发现过,而且这些化合物可能比不含卤素原子的化合物对野生动物更有害。 含氯和溴的PAC
及其烷基化衍生物将是这项由学生主导的研究的重点
程序.生物样本中发现的新化合物将推动第二次重大研究
这个研究项目的一部分。具体来说,我们将研究如何敏感这些化合物是代谢使用鱼肝微粒体生物测定。商业上
可用的标准品将用作底物,以了解代谢
这些化合物转化为极性更强的代谢物。除了
为了了解它们代谢的速度,我的HQP团队将鉴定在孵育生物测定过程中形成的代谢物。AOS地区野生动物中HPAC的鉴定以及鱼类中形成的代谢物将导致
关于持久性、生物累积性和毒性的未来研究活动
我们的团队(和其他人)将探索这些化合物。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Tomy, Gregg其他文献
Structure characterization and thermal stabilities of the isomers of the brominated flame retardant 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane
- DOI:
10.1016/j.chemosphere.2008.03.044 - 发表时间:
2008-07-01 - 期刊:
- 影响因子:8.8
- 作者:
Arsenault, Gilles;Lough, Alan;Tomy, Gregg - 通讯作者:
Tomy, Gregg
Bioaccumulation and trophic transfer of some brominated flame retardants in a Lake Winnipeg (Canada) food web
- DOI:
10.1897/05-500r.1 - 发表时间:
2006-08-01 - 期刊:
- 影响因子:4.1
- 作者:
Law, Kerri;Halldorson, Thor;Tomy, Gregg - 通讯作者:
Tomy, Gregg
Altered thyroxine metabolism in rainbow trout (Oncorhynchus mykiss) exposed to hexabromocyclododecane (HBCD)
- DOI:
10.1016/j.chemosphere.2010.03.016 - 发表时间:
2010-06-01 - 期刊:
- 影响因子:8.8
- 作者:
Palace, Vince;Park, Bradley;Tomy, Gregg - 通讯作者:
Tomy, Gregg
Validated quantitative cannabis profiling for Canadian regulatory compliance - Cannabinoids, aflatoxins, and terpenes
- DOI:
10.1016/j.aca.2019.08.042 - 发表时间:
2019-12-11 - 期刊:
- 影响因子:6.2
- 作者:
Brown, Alistair K.;Xia, Zhe;Tomy, Gregg - 通讯作者:
Tomy, Gregg
Tomy, Gregg的其他文献
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{{ truncateString('Tomy, Gregg', 18)}}的其他基金
Identification and environmental fate of novel halogenated polycyclic aromatic compounds in Canada's Oil Sands Region
加拿大油砂地区新型卤代多环芳香族化合物的鉴定和环境归趋
- 批准号:
RGPIN-2019-05354 - 财政年份:2022
- 资助金额:
$ 2.11万 - 项目类别:
Discovery Grants Program - Individual
Freshwater oil spill remediation study at the IISD-experimental lakes area: (The FOReSt Project)
IISD 实验湖区淡水溢油修复研究:(FOReSt 项目)
- 批准号:
532225-2018 - 财政年份:2021
- 资助金额:
$ 2.11万 - 项目类别:
Collaborative Research and Development Grants
Identification and environmental fate of novel halogenated polycyclic aromatic compounds in Canada's Oil Sands Region
加拿大油砂地区新型卤代多环芳香族化合物的鉴定和环境归趋
- 批准号:
RGPIN-2019-05354 - 财政年份:2021
- 资助金额:
$ 2.11万 - 项目类别:
Discovery Grants Program - Individual
Freshwater oil spill remediation study at the IISD-experimental lakes area: (The FOReSt Project)
IISD 实验湖区淡水溢油修复研究:(FOReSt 项目)
- 批准号:
532225-2018 - 财政年份:2020
- 资助金额:
$ 2.11万 - 项目类别:
Collaborative Research and Development Grants
Identification and environmental fate of novel halogenated polycyclic aromatic compounds in Canada's Oil Sands Region
加拿大油砂地区新型卤代多环芳香族化合物的鉴定和环境归趋
- 批准号:
RGPIN-2019-05354 - 财政年份:2019
- 资助金额:
$ 2.11万 - 项目类别:
Discovery Grants Program - Individual
Developing analytical environmental forensic techniques to identify new persistent and bioaccumlative chemicals
开发环境法医分析技术来识别新的持久性和生物累积性化学品
- 批准号:
RGPIN-2014-05303 - 财政年份:2018
- 资助金额:
$ 2.11万 - 项目类别:
Discovery Grants Program - Individual
Developing analytical environmental forensic techniques to identify new persistent and bioaccumlative chemicals
开发环境法医分析技术来识别新的持久性和生物累积性化学品
- 批准号:
RGPIN-2014-05303 - 财政年份:2017
- 资助金额:
$ 2.11万 - 项目类别:
Discovery Grants Program - Individual
Simultaneous determination of compounds in cannabis by liquid chromatography tandem mass spectrometry
液相色谱-串联质谱法同时测定大麻中的化合物
- 批准号:
522299-2017 - 财政年份:2017
- 资助金额:
$ 2.11万 - 项目类别:
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Two dimensional gas chromatographic analysis of alkylated polycyclic aromatic hydrocarbons
烷基化多环芳烃的二维气相色谱分析
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- 资助金额:
$ 2.11万 - 项目类别:
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开发环境法医分析技术来识别新的持久性和生物累积性化学品
- 批准号:
RGPIN-2014-05303 - 财政年份:2016
- 资助金额:
$ 2.11万 - 项目类别:
Discovery Grants Program - Individual
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- 资助金额:
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Discovery Grants Program - Individual