Purification of a potential novel natural pesticide from a tree species abundant on the Canadian west coast

一些加拿大西海岸的树叶含有一种天然植物次生代谢物，是天然农药的良好候选物。该提案旨在开发一种实用且可扩展的方法，从不列颠哥伦比亚省沿海的一种常见树种中纯化这种天然化合物。这个项目得到了Ecosafe天然产品公司的支持和促进，这是一家位于不列颠哥伦比亚省维多利亚附近的小型研发公司，专门从事天然产品的配方、产品开发和分析。这项工作将在我们位于维多利亚大学的实验室进行，但将与Ecosafe密切合作，以整合他们在大规模天然化合物纯化方面的专业知识。这项工作的长期目标是测试天然化合物的杀虫和抗生素特性。因此，通过开发一种有效的纯化策略，我们将能够获得足够的纯天然化合物，以进行一套针对害虫和微生物的生物分析和测试。这些化验将在下一阶段的工作中进行。最后，我们打算描述这种天然产物的生物活性特性、稳定性和功效，并评估其作为商业天然农药的潜力

Some Canadian West Coast tree leaves contain a natural plant secondary metabolite that is a good candidate for a naturally-sourced pesticide. This proposal aims to develop a practical and scalable method for purification of this natural compound from a common tree species in coastal British Columbia. This project is supported and facilitated by Ecosafe Natural Products Inc., a small R & D company based near Victoria, B.C, that specializes in formulation, product development and analysis of natural products. The work will be carried out in our laboratory at the University of Victoria, but in close collaboration with Ecosafe in order to integrate their expertise in large-scale purification of natural compounds. The long-term aim of the work is to test the pesticidal and antibiotic properties of the natural compound. Therefore, by developing an efficient strategy for purification, we will be able to obtain sufficient pure natural compound to carry out a suite of bioassays and tests against pest insects and microbes. These assays will be carried out in the next phase of the work. Ultimately, we intend to characterize the bioactive properties, stability, and efficacy of this natural product, and to evaluate its potential as a commercial natural pesticide.**