Investigation of the prebiotic properties of collagen hydrolysates

Genacol Canada Corporation Inc.生产一种牛源水解胶原蛋白补充剂（Genacol®**原始配方），在两项独立的临床试验中显示出减轻关节疼痛的功效。经过消化，水解的胶原蛋白会产生生物可利用的氨基酸和多肽，从而使补充剂具有促进健康的特性。然而，目前还没有关于肽是否能在消化过程中存活，从而对益生菌发挥益生元作用的信息，因为这可能是该产品对关节健康有益的一种机制。研究的一个挑战是，通常研究食物成分的益生元特性时使用发酵罐，而不考虑胃和小肠的消化过程。在本研究中，胃和小肠在一个动态模拟肠道消化模型中的消化将被用来生成肽，这些肽可以在含有益生菌的发酵罐中测试它们的益生元特性。这种方法是**确定Genacol胶原蛋白水解物是否具有益生元特性的第一步，这些特性可以作为减轻关节疼痛的作用机制进行促进和**研究。

Genacol Canada Corporation Inc. manufactures a bovine-sourced hydrolyzed collagen supplement (Genacol®**Original Formula), which has shown efficacy in two separate clinical trials for reducing joint pain. Following**digestion, hydrolyzed collagen yields bioavailable amino acids and peptides that can lead to the**health-promoting properties of the supplement. There is presently, however, no information as to whether the**peptides can survive digestive processes in order to exert prebiotic effects on probiotic bacteria as this could be**a mechanism for the joint health benefits of the product. A research challenge is that typically studies**examining prebiotic properties of food components use fermentors without consideration of the digestive**processes of the stomach and small intestine. In the present study, digestion of the stomach and small intestine**in a dynamic simulated gut digestion model will be used to generate peptides that can be tested for their**prebiotic properties with fermentors containing probiotic bacteria. This approach is the first step towards**identifying whether the Genacol collagen hydrolysate has prebiotic properties that can be promoted and**examined as a mechanism of action for the reduction of joint pain seen with this product.