Section for metallic 3D-printing at the Laboratory for Biomaterials and Bioengineering at U. Laval

具有非常规和极端性质的先进材料正在成为生物医学、工业、化工、机械、制药和光学等多个领域产生和推动创新的关键因素，从而确保竞争力并影响经济增长。毫无疑问，加法制造是最新、用途最广、潜力最大的材料加工技术之一。选择性激光熔化或原子扩散添加剂制造构成了制造具有定制成分的样品的两种创新方法，使得在相同的样品中产生成分梯度成为可能。在这项技术中，有可能将新的特征，如对选定细胞的更高抵抗力或生物吸引力，以一种非均质的方式，赋予广泛的底物，贯穿整个样品几何形状。*我们通过向NSERC提交的这份建议书建议收购的添加金属制造系统，是一种易于使用的设备，正在迅速成为学术实验室的黄金标准，这些实验室需要快速从设计到生产金属样品，以开发新合金并在制造后进行热机械处理后调整其性能。这个想法是为了探索添加制造用于医疗应用的新型可降解金属合金的潜力。临床上迫切需要临时设备来完成它们的使命，然后在不对人体产生毒性反应的情况下降解，这充分证明了这项研究的合理性。儿童先天性疾病、神经精确药物释放、手和上颌面部手术、一些整形外科缺陷的治疗、大多数心脏支架手术，以及其他将从新型先进制造材料的开发中受益匪浅。在COPIS中，人们已经研究了通过铸造、成形、电铸和粉末冶金来制造新型金属合金的潜力。结果表明，工艺对降解率有很大影响。研制具有目标降解率的新的金属可降解金属是当今该领域的主要挑战。这将允许根据患者的病理和设想的临床治疗为每个患者开发个性化的设备。这将有力地帮助拟议的团队有竞争力地展示他们在健康材料方面的基础研究工作的价值。*该设备预计将促进COPIS发现研究成果的创新应用，从而对研究成果进行评估，并探索成为造福于社会的真正产品的潜力。

Advanced materials, showing unconventional and extreme properties are becoming the key factors for generating and pushing innovation in a number of fields, including biomedical, industrial, chemical, mechanical, pharmaceutical, and optical thus guaranteeing competitiveness and impacting the economic growth. One of the most recent, versatile and high-potential material processing techniques is without any doubt additive manufacturing. Selective laser melting or atomic diffusion additive manufacturing constitute two innovative routes for fabricating specimens with tailored composition making possible to generate compositional gradients into the same specimens. Within this technique, it is potentially possible to confer new features such as higher resistance or biological attractiveness towards selected cells, to a wide range of substrates, in a non-homogenous way, all over the specimen geometry. ***The additive metal manufacturing system we propose to acquire by this proposal to NSERC, is an easy-to-use equipment that is fast becoming the gold standard in academic laboratories that require rapid design-to-production of metallic specimens for developing new alloys and modulating their properties after post-fabrication thermomechanical treatments. The idea is to explore the potential of additively manufacturing new degradable metallic alloys for medical applications. The urgent clinical need for temporary devices that fulfill their mission and then degrade without generating toxic reactions into the body fully justify this research. Pediatric congenital diseases, neurological precise releasing of medicaments, hands and maxilla-facial surgery, some orthopedic defects treatments, most of the cardiac stenting procedures, and others will greatly benefit from the development of a new class of advanced manufactured materials with tailored gradients. Within the coPIs, the potential of fabricating new metallic alloys by casting, forming, electroforming and powder metallurgy has already been investigated. Results clearly show that the process strongly affect the degradation rate. The elaboration of new metallic degradable metals with targetable degradation rate constitute today the main challenge in the field. This will allow to develop personalized devices for each patient and depending from his/her pathology and envisaged clinical treatment. This will strongly help the proposed team to competitively show the value of their fundamental research works on materials for health. ***This equipment is expected to boost the application of the results of the coPIs discovery researches toward innovation thus valorizing the output of the researches and exploring the potential to become true products for the benefit of the Society.