Effects of plasma treatment on natural materials - in particular polysaccharides - for biotechnological applications in health

自1970年以来，生物材料挽救和延长了世界各地数百万患者的生命。虽然已经取得了巨大的进展，但排斥反应仍然很常见，当植入时，sone 10%至40%的种植体的临床随访仍然受到影响。迫切需要寻找能够替代或刺激病区愈合和再生的材料和策略。在这方面，天然材料，即那些由自然产生的材料，如多糖和胶原蛋白，代表着再生和恢复性医学的有趣战略。科学文献和专利贸易办公室也已经探索、研究和报告了一些应用。这里的研究目标是一个合作项目，旨在开发创新的等离子体程序来修饰多糖结构的表面，以提高其生物学性能。以拉瓦尔大学CRC-1生物材料和生物工程实验室为中心的综合团队，包括两个高水平的工业合作伙伴，将允许这项研究的发展，同时为高素质人员提供培训。将涉及两名博士后研究员(每人24个月)、一名博士生、两名硕士和四名本科生。

Since 1970, biomaterials save and lengthen the life of millions of patients around the world. Although an enormous progress has been achieved, the reject reactions are still common, and when implanted, the clinical follow up of sone 10 to 40% of implants are still affected. The search for materials and strategies able to replace or to stimulate the healing and the regeneration of the diseased area is urgent. In this context, natural materials, i.e. those produced by nature, as polysaccharides and collagen, represent interesting strategies for regenerative and restorative medicine. A number of applications have already been explored, studied and reported in the scientific literature and patent trade offices as well. The research targeted here is a partnership project that aims to develop innovative plasma procedures to modify the surface of polysaccharide structures in order to improve their biological performances. A consolidated team centered around the Laboratory for Biomaterials and Bioengineering atLaval University, CRC-1, including two high-level industrial partners will allow the development of this research while providing training for high qualified personnel. Two postdoctoral fellows (24 months each), one PhD student, two master students and four undergraduate students, will be involved.