Evaluation and adapting of a new technology to monitor blood viscoelastic properties

Rheolution Inc.生产非接触式机械表征仪器，用于实时测量 ** 液体和软材料的粘弹性/流变特性。这些仪器用于食品 ** 行业（例如，牛奶凝固），并且在有限程度上，在关注生物材料和医疗设备技术的学术界和工业界（例如，水凝胶）。该公司正在通过研究其测量血液生物力学变化的技术并将其与凝血动力学相关联来探索其市场的潜在扩张。该NSERC Engage项目的目的是解决该公司在识别样品架所用材料的血液生物相容性和优化其 ** 技术在表征血液凝固方面的灵敏度方面的问题。全血 ** 粘弹特性的定量实时测量将与不同 ** 长度尺度下已建立的体外凝血测定相关。预计这将有助于Rheolution进行进一步的研究和 ** 开发，以修改其仪器，用于测量血液凝固的潜在应用。Rheolution的最终目标是为医院等临床实践以及专注于开发血液凝固剂或抗凝剂的行业提供设备。

Rheolution Inc. manufactures contactless mechanical characterization instruments for real-time measurement**of viscoelastic/rheological properties of liquids and soft materials. The instruments are used in the food**industry (e.g., milk coagulation), and to a limited extent, in academia and industries focused on biomaterial and**medical device technologies (e.g., hydrogels). The company is exploring the potential expansion of its markets**by investigating its technology in measuring changes in blood biomechanics and correlating these with**coagulation kinetics. The Aim of this NSERC Engage project is to solve the company problem in identifying**the blood biocompatibility of the materials used in its sample holders and optimizing the sensitivity of its**technology in characterizing blood coagulation. Quantitative real-time measurements of whole blood**viscoelastic properties will be correlated with established in vitro assays of coagulation at different**length-scales. It is anticipated that this will help enable Rheolution to undertake further research and**development in modifying its instruments for potential applications in measuring blood coagulation. Ultimately**the goal of Rheolution is to supply its equipment to clinical practices such as hospitals, as well as industries**focused on developing blood coagulants or anticoagulants.