Bioprocess Engineering of Mammalian Cell Culture

哺乳动物细胞培养已成为生产生物疗法的主要技术。这些培养物也越来越多地用于研究和开发新的免疫疗法和干细胞疗法，用于治疗损伤和慢性疾病。这些新兴疗法的巨大前景伴随着巨大的挑战，其中许多挑战来自细胞培养过程工程领域。******该项目的长期目标是使哺乳动物细胞产品的生产更安全、更经济。这将通过最近开发的技术来实现，以进行新颖的研究，这将增加对细胞培养过程的理解。因此，我们应该为加速工艺开发以及更有效地优化生物工艺做出贡献。这将包括在相对简单的哺乳动物细胞蛋白制造背景下的工作，以及更复杂的治疗性细胞培养分析。特别是，将开发改进的过程分析技术，以大大增加对哺乳动物细胞培养群体的高通量分析，并加速最适合制造的特定细胞的选择。******开发可靠和经济的哺乳动物细胞制造手段对于确保许多有前途的新兴保健技术实际上广泛地提供给需要它们的患者至关重要。最终，增加获得安全和负担得起的细胞培养产品的机会将改善成千上万加拿大人的生活质量。UBC和加拿大多学科小组在这一研究领域处于领先地位。出口这些技术和知识应使世界各地的人民受益，并为加拿大人带来可观的商业利益。**

Mammalian cell cultures have become the dominant technology for the production of biological therapeutics. These cultures are also increasingly used for the research and development of novel immunotherapies and stem cell therapies, used to treat injuries and chronic diseases. The great promise of these emerging treatments comes with great challenges, many of those in the field of cell culture process engineering. ******The long-term goal of this program is to enable safer and more economical manufacture of mammalian cell products. This will be achieved by recently developed technologies to perform novel research that will increase the understanding of cell culture processes. We should thereby contribute both to accelerated process development as well more effectively optimized bioprocesses. This will include work in the relatively simple context of mammalian cell protein manufacturing, as well as the more complex analysis of therapeutic cell cultures. In particular, improved process analytical technologies will be developed to greatly increase the high-throughput analysis of mammalian cell culture populations and accelerate the selection of specific cells that are most suitable for manufacturing.******The development of reliable and economical means of mammalian cell manufacturing is essential to ensure that many promising emerging health care technologies actually become widely available to the patients who need them. Ultimately, increased access to safe and affordable cell culture products will improve the quality of many thousands of Canadian lives. UBC and Canadian multidisciplinary groups are among the leaders in this area of research. Exporting these technologies and knowledge should benefit populations around the world as well as translate into substantial commercial benefits for Canadians. **