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CIHR Team in Palmitoylation in Huntington Disease

CIHR Team in Palmitoylation in Huntington Disease
CIHR 团队在亨廷顿病棕榈酰化方面的研究
批准号：
188121
负责人：
Hayden Michael R
金额：
$181.43万
依托单位：
University of British Columbia
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2009
资助国家：
加拿大
项目状态：
已结题
起止时间：
2009-06-01 至 2014-06-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=188121&lang=en
关键词：
Huntington Disease Lipid Modification Palmitoylation Assays And Screens Protein Trafficking Synaptic Function

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中文摘要
翻译
蛋白质棕榈酰化是一种动态调节的翻译后修饰，对正确的细胞运输至关重要。我们最近的研究表明，棕榈酰化的缺陷，选定的神经元蛋白与亨廷顿病。我们将
英文摘要
Protein palmitoylation is a dynamically regulated posttranslational modification critical for proper cellular trafficking. Our recent studies show that defects in palmitoylation of selected neuronal proteins are associated with Huntington Disease. We will
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会议论文
Allele-specific lowering of mutant polyQ proteins as treatment for Huntington disease, spinocerebellar ataxia type 3 and spinocerebellar ataxia type 7
Novel Approaches Directed to Prevention and Treatment of Huntington Disease
Canada Research Chair Tier 1
  • 批准号：
    315426
  • 项目类别：
  • 资助金额：
    $101.99万
  • 财政年份：
    2014
  • 负责人：
    Hayden Michael R
  • 依托单位：
    University of British Columbia
Novel approaches to modulate key targets in the pathogenesis of Huntington Disease
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