RNA Bioinformatics and Genomics

本研究计划在RNA生物信息学、人类遗传学和生物化学的融合基础上，鉴定人类体内新的非编码RNA。它将集中在四类非编码rna，迄今为止还没有广泛的研究，包括重复，嵌合和环状rna。RNA测序和分析管道将被优化，以便检测这些RNA，同时它们的结构和与蛋白质的相互作用将在体外进行测试。这项研究将有助于更好地理解人类非编码转录组的结构和变异性，以及这些rna在细胞功能中的作用。

This research program aims to identify novel non-coding RNAs in human based on the convergence of RNA bioinformatics, human genetics and biochemistry. It will focus on four classes of non-coding RNAs that have not been studied extensively until now, including repetitive, chimeric and circular RNAs. RNA sequencing and analysis pipelines will be optimized to allow detection of these RNAs while their structure and interaction with proteins will be tested in vitro. This research will contribute to a better understanding of the architecture and the variability of the non-coding transcriptome in human and the role of these RNAs in cellular function.