Sparse integrated computational optical imaging systems

集成计算光学成像(ICOI)是一种非常有前途的方法，它涉及到改进的光学硬件和数字处理算法的联合设计，以获得高分辨率、大视场、高帧频的成像性能，而这些性能是未经修改的系统所无法达到的。为了克服带宽限制(空间光学相干层析成像(OCT)是一种重要的亚表面成像方式)，在许多医疗和工业应用中。它的分辨率比超声高一到两个数量级，在生物组织中的典型成像深度为(~2 mm)。开发了实时亚微米分辨率压缩传感全场OCT系统2.开发并实现了OCT图像中血管斑块的实时稀疏检测。开发一种方法来扩大高NA(放大倍率)显微镜的景深(&gt；10倍)。推广我们的OCT系统模拟器，以允许有限宽度光束成像。我们预计我们拟议的研究将产生很高的影响，因为1)我们新的全场OCT系统将允许3D细胞成像细胞深度达到850微米，而目前共焦显微镜允许的成像深度为100微米；2)在不损失横向分辨率、光学功率或物镜工作距离的情况下，扩展高NA(放大倍率)光学显微镜的景深的能力，将对广泛的科学和工业应用产生强烈的积极影响；3)我们预计所提出的扩展景深显微镜和所提出的从OCT图像中实时检测血管斑块的商业化潜力很高；4)实用、准确和快速的OCT系统计算机模拟器的可用性将是实现和/或促进未来更高性能OCT系统设计的一个非常有用的工具。拟议的研究计划还将创造独特的机会，培养两名博士和两名硕士。以及成像系统、光学、数据采集、图像处理和高级计算理论和实践方面的5名本科生。

Integrated Computational Optical Imaging (ICOI) is a highly promising approach that involves the joint design of modified optical hardware and digital processing algorithms to achieve imaging performance, e.g., high resolution, large field-of-view, high frame rates, that would otherwise be unattainable by the unmodified system.To overcome bandwidth limitations (spatial Optical coherence tomography (OCT) is an important sub-surface imaging modality for numerous medical and industrial applications. It has one to two orders of magnitude higher resolution than ultrasound and typical imaging depth of (~ 2 mm) in biological tissue.1. Develop a real-time submicron-resolution compressed sensing full field OCT system 2. Develop & implement real-time sparse detection of vascular plaque from OCT images3. Develop a method to extend depth-of-field (>10 times) of high NA (magnification) microscope4. Generalize our OCT system simulator to allow imaging with finite-width light beams.We anticipate a high impact of our proposed research because 1) our novel full field - OCT system would allow 3D cell imaging cells up to a depth of 850 µ m compared to the 100 µ m imaging depth currently allowed by confocal microscopy; 2) the ability to extend the depth-of-field of high NA (magnification) optical microscopes, without loss of lateral resolution, optical power, or objective's working distance, would have a strong positive impact on a wide variety of scientific and industrial applications; 3) we anticipate a high potential for commercialization for the proposed extended depth-of-field microscopy and the proposed real-time detector of vascular plaque w from OCT images; 4) the availability of a practical, accurate and fast computer simulator of OCT systems would be an extremely useful tool to enable and/or facilitate future design of higher performance OCT systems. The proposed research program will also create unique opportunities to train 2 Ph.D. and 2 M.Sc. and 5 undergraduate students in both theoretical and practical aspects of Imaging Systems, Optics, Data Acquisition, Image Processing and Advanced Computing.